Anti-Human FGFR2 Recombinant Antibody (GP369/4B9)
CAT#: TAB-055WM
Recombinant monoclonal antibody to FGFR2. Clone GP369/4B9 is a mouse monoclonal antibody which can be potentially used to treat cell proliferative diseases and disorders, including certain forms of cancer, associated with activation or overexpression of FGFR2.
Tested Data
Gene Expression
SDS-PAGE
Figure 1 Anti-FGFR2 Antibody (TAB-055WM) in SDS-PAGE
SDS-PAGE analysis of TAB-055WM in non-reduced (Lane 1) and β-mercaptoethanol-reduced (Lane 2) conditions.
SEC-HPLC
Figure 2 Anti-FGFR2 Recombinant Antibody (TAB-055WM) in HPLC
The purity of TAB-055WM was greater than 95% as determined by SEC-HPLC.
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Subcellular Location
Figure 1 IF staining of human cell line HEK 293
Immunofluorescent staining of human cell line HEK 293 shows localization to nucleoplasm, cell junctions & vesicles.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/35305/if_selected.jpg
Normal Tissue
Figure 2 IHC staining of human stomach
Immunohistochemical staining of human stomach shows strong cytoplasmic positivity in parietal cells.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/35305/ihc_selected.jpg
Normal Tissue
Figure 3 IHC staining of human skin
Immunohistochemical staining of human skin shows strong ctyoplasmic positivity in keratinocytes.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/10886/26036_B_7_1_selected.jpg
Normal Tissue
Figure 4 Cerebral cortex
Neuronal cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/10886/26036_B_7_5.jpg
Normal Tissue
Figure 5 Colon
Endothelial cells Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous Glandular cells Staining: Low Intensity: Weak Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/10886/26036_A_7_3.jpg
Normal Tissue
Figure 6 Testis
Cells in seminiferous ducts Staining: Low Intensity: Moderate Quantity: <25% Location: Cytoplasmic/ membranous Leydig cells Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/10886/26036_A_4_6.jpg
Normal Tissue
Figure 7 Lymph node
Non-germinal center cells Staining: Low Intensity: Moderate Quantity: <25% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/10886/26036_A_9_8.jpg
RNA Expression
Figure 8 RNA cell line category: Cell line enhanced (AN3-CA, BEWO, CACO-2, HaCaT, HAP1, NTERA-2, T-47d)
Cell lines ordered by descending RNA expression order
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000066468-FGFR2
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Specifications
- Immunogen
- A 1: 1 mixture of human FGFR2 IgD2-IgD3 (Illb) and human FGFR2 IgD2-IgD3 (IIIc) fused with a human Fc moiety at their C-termini
- Host Species
- Mouse
- Specificity
- Human
- Species Reactivity
- Human
- Clone
- GP369/4B9
- Applications
- FC
- Related Disease
- Cell proliferative diseases
Applications
- Application Notes
- The FGFR2 antibody has been reported in applications of Flow Cytometry.The cells were incubated with 100 μL of primary FGFR2 antibodies (5 μg/mL) for 1 h, followed by incubation with 1:100 phycoerythrin (PE)-conjugated secondary antibodies (Jackson ImmunoResearch) for 30 min.
Target
- Alternative Names
- FGFR2; fibroblast growth factor receptor 2; BEK; JWS; BBDS; CEK3; CFD1; ECT1; KGFR; TK14; TK25; BFR-1; CD332; K-SAM; FGFR-2; FGF receptor; soluble FGFR4 variant 4; bacteria-expressed kinase; hydroxyaryl-protein kinase; FGFR2-AHCYL1 fusion kinase protein; keratinocyte growth factor receptor; BEK fibroblast growth factor receptor; protein tyrosine kinase, receptor like 14
- Gene ID
- 2263
- UniProt ID
- P21802
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Detailed Documentation
The antibody comes with extensive and detailed documentation, including usage protocols and validation data. Makes experimental planning and execution straightforward.
Rapid Delivery
The product was delivered quickly and in excellent condition. Prompt services along with an outstanding product redefine the user experience.
Robust for Multiple Assays
Very robust antibody, suitable for various research applications. We used it in cell-based assays with consistent performance across the board.
Q&As
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Does this antibody require any special handling precautions?
A: Standard laboratory precautions should be practiced. Avoid repeated freeze-thaw cycles.
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What quality control tests are performed on this antibody?
A: This antibody undergoes testing for purity, specificity, and activity in relevant applications.
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Is bulk availability an option for this antibody?
A: Yes, bulk quantities are available upon request.
View the frequently asked questions answered by Creative Biolabs Support.
Cite This Product
To accurately reference this product in your publication, please use the following citation information:
(Creative Biolabs Cat# TAB-055WM, RRID: AB_3111782)
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Related Diseases
EGFR Tyrosine Kinase Inhibitor Resistance
Downloadable Resources
Download resources about recombinant antibody development and antibody engineering to boost your research.
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number:
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